Reverse Rett Minneapolis is an annual cocktail event that benefits the Rett syndrome Research Trust, a non-profit that is leading the charge to develop a cure for Rett Syndrome. Rett syndrome is a devastating neurological disorder that afflicts 350,000 children and adults around the world. It affects almost exclusively females. With the exception of women's cancers, Rett is the leading genetic cause of sever impairment in females.